Proprietary Technologies

Concentric Multiple-Particulate Delivery System (CMDS)
US Patent 5,885,616
Many of today’s controlled-release technologies are designed for the release of only one active ingredient with one rate of release. This release profile may not be adequate for drugs in certain therapeutic categories. Our CMDS technology is designed to control the release rate of multiple active ingredients in a multi-particulate dosage form. This technology allows us to overcome one of the technical challenges in the development of multi-particulate dosage forms – achieving acceptable uniformity and reproducibility of a product with a variety of active ingredients. Our CMDS technology is designed to allow for the release of each of the active ingredients through an encapsulated form at predetermined time intervals and desired levels on a consistent basis.

Timed Multiple-Action Delivery System (TMDS)
US Patent 6,372,254; US Patent 6,7301,321
Similar to CMDS, this system controls release rates for multiple ingredients within a single table in a programmed manner. Our TMDS technology allows for the release of more than one active ingredient in a single tablet formulation to be released in multiple profiles over time.

Dividable Multiple-Action Delivery System (DMDS)
US Patent 6,602,521
Our proprietary DMDS system is an extension of our CMDS and TMDS technologies. It is designed to provide greater dosing flexibility which improves product efficacy and reduces side effects. Traditional controlled-release tablets often lose their “controlled” mechanism of delivery once broken. Our DMDS technology allows the tablet to be broken in half so that each respective portion of the tablet will achieve exactly the same release profile as the whole tablet. This allows the patient and physician to adjust the dosing regimen according to the clinical needs without compromising efficacy.

Particle Dispersion Systems (PDS)
US Patent 6,531,158
One of the challenges in the formulation of an insoluble drug is to achieve satisfactory bioavailability in humans. Our proprietary PDS system provides a drug delivery system for the oral administration of water insoluble inactive ingredients.

Pharmaceutical Stabilization System (PSS)
US Patent 6,333,332
Our PSS system is designed to create an acidic micro-environment for drugs which require an acidic environment to achieve optimal stability. We achieve this environment through the addition of an organic acid using several salts which retard the degradation of, and therefore stabilize, certain active ingredients.